Name: U-Blot® TSH Mouse mAb (Ready to Use)
SKU: WM1640R
Price: 168 USD
Availability: InStock

Product details

Background：
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013],

Specifications

Target	TSHB
Reactivity	Human
Applications	IHC
MW(Calculated)
MW(Observed)
Host Species	Mouse
Isotype	IgG1,Lambda
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	Ready to use for IHC / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Formulation	The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
Source
Purification	The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Purity
Storage	2°C to 8°C/1 year,Ship by ice bag
Concentration
Clonality	Monoclonal
Clone Number	ABT-TSH
Immunogen	Synthesized peptide derived from human Thyroid-Stimulating Hormone(TSH) AA range: 50-138
Sequence
Specificity	The antibody can specifically recognize human TSH protein.
Gene Name	TSHB
Protein Name	Thyrotropin subunit beta (Thyroid-stimulating hormone subunit beta) (TSH-B) (TSH-beta) (Thyrotropin beta chain) (Thyrotropin alfa)
Other Name
Species	Human
Gene ID-1	7252
Uniprot	P01222
Species.1
Gene ID-2
Uniprot.1
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto' s thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013],
Cellular Localization	Cytoplasmic
Tissue Expression
Signaling_pathway	Human Diseases >> Immune disease >> Autoimmune thyroid disease;Environmental Information Processing >> Signal transduction >> cAMP signaling pathway
Research Areas	>>cAMP signaling pathway; / >>Neuroactive ligand-receptor interaction; / >>Thyroid hormone synthesis; / >>Regulation of lipolysis in adipocytes; / >>Autoimmune thyroid disease
Function	Function:Indispensable for the control of thyroid structure and metabolism.,online information:Clinical information on Thyrogen,online information:Thyroid-stimulating hormone entry,pharmaceutical:Available under the name Thyrogen (Genzyme). Used in combination with other tests to detect recurring or leftover thyroid cancer cells in patients with a history of certain types of thyroid cancer.,similarity:Belongs to the glycoprotein hormones subunit beta family.,subunit:Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.,
RRID