Name: U-Blot® ULA1 Rabbit mAb
SKU: WR6063
Price: 268 USD
Availability: InStock

U-Blot® ULA1 Rabbit mAb

Ucallm_WR6063-50

Price range: $268.00 through $328.00

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50μl

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SKU: WR6063-50

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Product details

Background：
The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties , and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition , the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8 , a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq , Jul 2008] ,

Specifications

Size	50μL/100μL
Target	ULA1
Reactivity	Human, Rat
Applications	WB, IHC, IF, IP, ELISA
MW(Calculated)	60kD
MW(Observed)	60kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM1976R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	NAE1 APPBP1 HPP1
Protein Name	NEDD8-activating enzyme E1 regulatory subunit (Amyloid beta precursor protein-binding protein 1, 59 kDa) (APP-BP1) (Amyloid protein-binding protein 1) (Proto-oncogene protein 1)
Other Name
Species	Human
Gene ID	8883
Uniprot	Q13564,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q8VBW6,
Species.2	Rat
Gene ID.2
Uniprot.2	Q9Z1A5
Cellular Localization	Cell membrane . Colocalizes with APP in lipid rafts.
Tissue Expression	Ubiquitous in fetal tissues. Expressed throughout the adult brain.
Signaling_pathway	Human Diseases >> Neurodegenerative disease >> Alzheimer disease
Research Areas	>>Alzheimer disease
Function	Caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,enzyme regulation:Binding of TP53BP2 to the regulatory subunit NAE1 decreases neddylation activity.,Function:Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.,miscellaneous:NAE1 and UBA3 correspond to the N-terminal and the C-terminal part of yeast UBA3. In yeast the two subunits form a single polypeptide chain.,pathway:Protein modification; protein neddylation.,similarity:Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.,subcellular location:Colocalizes with APP in lipid rafts.,subunit:Heterodimer of UBA3 and NAE1. The complex binds NEDD8 and UBE2M. Binds APP and TP53BP2.,tissue specificity:Ubiquitous in fetal tissues. Expressed throughout the adult brain.,