Price range: $268.00 through $328.00
Background:
This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis, and regulation of other cell signaling pathways. [provided by RefSeq, Aug 2010],
| Size | 50μL/100μL |
| Target | UBC |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 75kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human UBC AA range: 160-210 |
| Specificity | This antibody detects endogenous levels of UBC at Human/Mouse/Rat |
| Gene Name | UBC |
| Protein Name | UBC |
| Other Name | |
| Species | Human |
| Gene ID | |
| Uniprot | P0CG48, |
| Species.1 | Mouse |
| Gene ID.1 | 22190 |
| Uniprot.1 | P0CG50, |
| Species.2 | Rat |
| Gene ID.2 | 50522 |
| Uniprot.2 | Q63429 |
| Cellular Localization | [Ubiquitin]: Cytoplasm . Nucleus . Mitochondrion outer membrane; Peripheral membrane protein . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | >>PPAR signaling pathway; / >>Ubiquitin mediated proteolysis; / >>Mitophagy - animal; / >>Parkinson disease; / >>Pathways of neurodegeneration - multiple diseases; / >>Shigellosis; / >>Kaposi sarcoma-associated herpesvirus infection |
| Function | Function:Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous functions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair.,miscellaneous:This ribosomal protein is synthesized as a C-terminal extension protein (CEP) of ubiquitin.,miscellaneous:Ubiquitin is synthesized as a polyubiquitin precursor with exact head to tail repeats, the number of repeats differ between species and strains. In some species there is a final amino-acid after the last repeat, here in human a Val. Some ubiquitin genes contain a single copy of ubiquitin fused to a ribosomal protein (either L40 or S27a).,PTM:Several types of polymeric chains can be formed, depending on the lysine used for the assembly.,similarity:Belongs to the ribosomal protein S27Ae family.,similarity:Belongs to the ubiquitin family., |
