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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/UBC9 rabbit pAb
SKU: WP17794 Categories: ,

UBC9 rabbit pAb

Ucallm_WP17794-50

Price range: $268.00 through $328.00

SKU: WP17794-100
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Product details

Background:

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetUBC9
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)17kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:1000-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human UBC9
SpecificityThis antibody detects endogenous levels of Human UBC9
Gene NameUBE2I UBC9 UBCE9
Protein NameSUMO-conjugating enzyme UBC9
Other NameUBE2I; / UBC9; / UBCE9; / SUMO-conjugating enzyme UBC9; / SUMO-protein ligase; / Ubiquitin carrier protein 9; / Ubiquitin carrier protein I; / Ubiquitin-conjugating enzyme E2 I; / Ubiquitin-protein ligase I; / p18
SpeciesHuman
Gene ID7329
UniprotP63279,
Species.1Mouse
Gene ID.1100044900
Uniprot.1P63280,
Species.2Rat
Gene ID.225573
Uniprot.2P63281
Cellular LocalizationNucleus . Cytoplasm . Cytoplasm, perinuclear region . Mainly nuclear (By similarity). In spermatocytes, localizes in synaptonemal complexes (PubMed:8610150). Recruited by BCL11A into the nuclear body (By similarity). .
Tissue ExpressionExpressed in heart, skeletal muscle, pancreas, kidney, liver, lung, placenta and brain. Also expressed in testis and thymus.
Signaling_pathwayHuman Diseases >> Cancer: overview >> MicroRNAs in cancer;Environmental Information Processing >> Signal transduction >> NF-kappa B signaling pathway;Genetic Information Processing >> Translation >> Nucleocytoplasmic transport;Genetic Information Processing >> Folding, sorting and degradation >> Ubiquitin mediated proteolysis
Research Areas>>Nucleocytoplasmic transport; / >>NF-kappa B signaling pathway; / >>Ubiquitin mediated proteolysis; / >>MicroRNAs in cancer
FunctionCatalytic activity:ATP + SUMO + protein lysine = AMP + diphosphate + protein N-SUMOyllysine.,Function:Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Essential for nuclear architecture and chromosome segregation.,pathway:Protein modification; protein sumoylation.,similarity:Belongs to the ubiquitin-conjugating enzyme family.,subunit:Interacts with HIPK1, HIPK2 and PPM1J (By similarity). Forms a tight complex with RANGAP1 and RANBP2. Interacts with SIAH1 and PARP. Interacts with various transcription factors such as TCF3, TFAP2A, TFAP2B, TFAP2C, AR, ETS1 and SOX4. Interacts with human adenovirus E1A and human herpesvirus 6 IE2. Interacts with RWDD3; the interaction enhances the sumoylation of a number of proteins such as HIF1A and I-kappa-B.,tissue specificity:Expressed in heart, skeletal muscle, pancreas, kidney, liver, lung, placenta and brain. Also expressed in testis and thymus.,
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