SKU: WP1527 Categories: ,

UBE2W Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP1527-100
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Product details

Background:

This gene encodes a nuclear-localized ubiquitin-conjugating enzyme (E2) that, along with ubiquitin-activating (E1) and ligating (E3) enzymes, coordinates the addition of a ubiquitin moiety to existing proteins. The encoded protein promotes the ubiquitination of Fanconi anemia complementation group proteins and may be important in the repair of DNA damage. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],

Specifications

Size50μL/100μL
TargetUBE2W
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)16kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human protein . at AA range: 90-170
SpecificityUBE2W Polyclonal Antibody detects endogenous levels of protein.
Gene NameUBE2W UBC16
Protein NameUbiquitin-conjugating enzyme E2 W (Ubiquitin carrier protein W) (Ubiquitin-conjugating enzyme 16) (UBC-16) (Ubiquitin-protein ligase W)
Other Name
SpeciesHuman
Gene ID55284
UniprotQ96B02,
Species.1Mouse
Gene ID.1
Uniprot.1Q8VDW4,
Species.2Rat
Gene ID.2
Uniprot.2B5DEI4
Cellular LocalizationNucleus . In the nucleus, colocalizes with FANCL. .
Tissue ExpressionWidely expressed, with highest expression in brain, liver, pancreas and heart.
Signaling_pathwayGenetic Information Processing >> Folding, sorting and degradation >> Ubiquitin mediated proteolysis
Research Areas>>Ubiquitin mediated proteolysis
FunctionCatalytic activity:ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.,Function:Catalyzes the covalent attachment of ubiquitin to other proteins.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the ubiquitin-conjugating enzyme family.,subunit:Homodimer.,
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