Product details
Background:
- Please choose product options by visiting SLC3A1 rabbit pAb.
- Please choose product options by visiting ACSL6 Polyclonal Antibody.
- Please choose product options by visiting ZN428 rabbit pAb.
- Please choose product options by visiting SLC36A4 rabbit pAb.
UBL4A rabbit pAb
Ucallm_WP17887-50
Price range: $268.00 through $328.00
Specifications
| Target | UBL4A |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, WB |
| MW(Calculated) | 17kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004) |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human N-ternal UBL4A |
| Sequence | |
| Specificity | This antibody detects endogenous levels of UBL4A at Human, Mouse,Rat |
| Gene Name | UBL4A DXS254E GDX UBL4 |
| Protein Name | Ubiquitin-like protein 4A (Ubiquitin-like protein GDX) |
| Other Name | Ubiquitin-like protein 4A; / Ubiquitin-like protein GDX |
| Species | Human |
| Gene ID-1 | 8266 |
| Uniprot | P11441, |
| Species.1 | Mouse |
| Gene ID-2 | 27643 |
| Uniprot.1 | P21126, |
| Species.2 | Rat |
| Gene ID-3 | 293864 |
| Uniprot.2 | B2GV38 |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | |
| Cellular Localization | Cytoplasm, cytosol . Nucleus . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | |
| Function | As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation . The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum . Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome . Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum . The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome . |
| RRID |
Please login to post questions
Related products
