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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/UBP1 Polyclonal Antibody
SKU: WP1883 Categories: ,

UBP1 Polyclonal Antibody

Ucallm_WP1883-50

Price range: $268.00 through $328.00

SKU: WP1883-100
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Product details

Background:

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetUBP1
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)86kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein
SpecificityUBP1 Polyclonal Antibody detects endogenous levels of protein.
Gene NameUSP1
Protein NameUbiquitin carboxyl-terminal hydrolase 1 (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1)
Other Name
SpeciesHuman
Gene ID7398
UniprotO94782,
Species.1Mouse
Gene ID.1
Uniprot.1Q8BJQ2,
Species.2Rat
Gene ID.2
Uniprot.2Q569C3
Cellular LocalizationNucleus .
Tissue ExpressionBrain,Epithelium,Eye,Fetal brain,Testis,Uterus,
Signaling_pathway
Research Areas>>Fanconi anemia pathway
FunctionCatalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,developmental stage:Cell cycle-regulated. Highest level during S phase.,Function:Negative regulator of DNA damage repair. Autocatalytic cleavage of USP1 leads to an increase in ubiquitinated PCNA, recruitment of POLH and translesion synthesis following DNA damage. Regulates ubiquitination of FANCD2.,miscellaneous:HEK293T cells expressing reduced levels of USP1 show a higher level of ubiquitinated PCNA and an increase in point mutations upon UV irradiation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Ubiquitinated. Degraded by the proteasome.,sequence Caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the peptidase C19 family.,subunit:Interacts with FANCD2.,
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