UBP1 Polyclonal Antibody
Ucallm_WP1883-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | UBP1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 86kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | UBP1 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | USP1 |
| Protein Name | Ubiquitin carboxyl-terminal hydrolase 1 (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) |
| Other Name | |
| Species | Human |
| Gene ID | 7398 |
| Uniprot | O94782, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8BJQ2, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q569C3 |
| Cellular Localization | Nucleus . |
| Tissue Expression | Brain,Epithelium,Eye,Fetal brain,Testis,Uterus, |
| Signaling_pathway | |
| Research Areas | >>Fanconi anemia pathway |
| Function | Catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,developmental stage:Cell cycle-regulated. Highest level during S phase.,Function:Negative regulator of DNA damage repair. Autocatalytic cleavage of USP1 leads to an increase in ubiquitinated PCNA, recruitment of POLH and translesion synthesis following DNA damage. Regulates ubiquitination of FANCD2.,miscellaneous:HEK293T cells expressing reduced levels of USP1 show a higher level of ubiquitinated PCNA and an increase in point mutations upon UV irradiation.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,PTM:Ubiquitinated. Degraded by the proteasome.,sequence Caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the peptidase C19 family.,subunit:Interacts with FANCD2., |
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