SKU: WP3537 Categories: ,

UBP21 rabbit pAb

Price range: $268.00 through $328.00

SKU: WP3537-100
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Product details

Background:

This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016],

Specifications

Size50μL/100μL
TargetUBP21
ReactivityHuman, Mouse, Rat
ApplicationsWB
MW(Calculated)
MW(Observed)60kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human UBP21 AA range: 50-100
SpecificityThis antibody detects endogenous levels of UBP21 at Human/Mouse/Rat
Gene NameUSP21 USP23 PP1490
Protein NameUBP21
Other NameUbiquitin carboxyl-terminal hydrolase 21; / Deubiquitinating enzyme 21; / Ubiquitin thioesterase 21; / Ubiquitin-specific-processing protease 21
SpeciesHuman
Gene ID27005
UniprotQ9UK80,
Species.1Mouse
Gene ID.130941
Uniprot.1Q9QZL6,
Species.2Rat
Gene ID.2688466
Uniprot.2B2GUX4
Cellular LocalizationCytoplasm . Nucleus .
Tissue ExpressionHighly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta, liver and kidney, and at very low level in lung.
Signaling_pathwayCellular Processes >> Cell growth and death >> Necroptosis
Research Areas>>Necroptosis
FunctionCatalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,Function:Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates.,similarity:Belongs to the peptidase C19 family. USP21 subfamily.,tissue specificity:Highly expressed in heart, pancreas and skeletal muscle. Also expressed in brain, placenta, liver and kidney, and at very low level in lung.,
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