Price range: $268.00 through $328.00
Background:
Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM, Mar 2008],
| Size | 50μL/100μL |
| Target | UBP25 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 116kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human UBP25 AA range: 883-933 |
| Specificity | This antibody detects endogenous levels of UBP25 at Human/Mouse |
| Gene Name | USP25 USP21 |
| Protein Name | UBP25 |
| Other Name | |
| Species | Human |
| Gene ID | 29761 |
| Uniprot | Q9UHP3, |
| Species.1 | Mouse |
| Gene ID.1 | 30940 |
| Uniprot.1 | P57080 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm .; [Isoform USP25m]: Cytoplasm . Nucleus . Some transient punctuate nuclear location in myotubes during myocyte development. . |
| Tissue Expression | Isoform USP25a is found in most adult and fetal tissues; expression is moderately high in testis, pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, but very low in peripheral blood, colon, small intestine, ovary, prostate, thymus and spleen. Isoform USP25b is found in all tissues except heart and skeletal muscle. Isoform USP25m is heart and skeletal muscle specific. |
| Signaling_pathway | Organismal Systems >> Immune system >> IL-17 signaling pathway |
| Research Areas | >>IL-17 signaling pathway |
| Function | Catalytic activity:Ubiquitin C-terminal thioester + H(2)O = ubiquitin + a thiol.,Function:Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome.,similarity:Belongs to the peptidase C19 family.,similarity:Contains 2 UIM (ubiquitin-interacting motif) repeats.,tissue specificity:Found in most adult and fetal tissues; expression is moderately high in testis, pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, but very low in peripheral blood, colon, small intestine, ovary, prostate, thymus and spleen., |
