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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/ULK1 Polyclonal Antibody
SKU: WP14937 Categories: ,

ULK1 Polyclonal Antibody

Ucallm_WP14937-50

Price range: $268.00 through $328.00

SKU: WP14937-100
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Product details

Background:

catalytic activity:ATP + a protein = ADP + a phosphoprotein., function:Involved in axon growth. Plays an essential role in neurite extension of cerebellar granule cells., similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily., similarity:Contains 1 protein kinase domain., subunit:Interacts with GABARAP and GABARAPL2., tissue specificity:Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung.,

Specifications

Size50μL/100μL
TargetULK1
ReactivityHuman, Mouse
ApplicationsIHC, IF, WB, ELISA
MW(Calculated)113kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from the C-terminal region of human ULK1.
SpecificityULK1 Polyclonal Antibody detects endogenous levels of ULK1 protein.
Gene NameULK1
Protein NameSerine/threonine-protein kinase ULK1
Other NameULK1; / KIAA0722; / Serine/threonine-protein kinase ULK1; / Autophagy-related protein 1 homolog; / ATG1; / hATG1; / Unc-51-like kinase 1
SpeciesHuman
Gene ID8408
UniprotO75385,
Species.1Mouse
Gene ID.122241
Uniprot.1O70405
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCytoplasm, cytosol . Preautophagosomal structure . Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome. .
Tissue ExpressionUbiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung.
Signaling_pathwayCellular Processes >> Transport and catabolism >> Autophagy - animal;Cellular Processes >> Transport and catabolism >> Mitophagy - animal;Organismal Systems >> Aging >> Longevity regulating pathway;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Huntington disease;Human Diseases >> Neurodegenerative disease >> Spinocerebellar ataxia;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases;Environmental Information Processing >> Signal transduction >> AMPK signaling pathway;Environmental Information Processing >> Signal transduction >> mTOR signaling pathway
Research Areas>>Mitophagy - animal; / >>Autophagy - animal; / >>mTOR signaling pathway; / >>AMPK signaling pathway; / >>Longevity regulating pathway; / >>Alzheimer disease; / >>Amyotrophic lateral sclerosis; / >>Huntington disease; / >>Spinocerebellar ataxia; / >>Pathways of neurodegeneration - multiple diseases
FunctionCatalytic activity:ATP + a protein = ADP + a phosphoprotein.,Function:Involved in axon growth. Plays an essential role in neurite extension of cerebellar granule cells.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Interacts with GABARAP and GABARAPL2.,tissue specificity:Ubiquitously expressed. Detected in the following adult tissues: skeletal muscle, heart, pancreas, brain, placenta, liver, kidney, and lung.,
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