Price range: $268.00 through $328.00
Background:
This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010],
| Target | Unc18-1 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 68kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:40000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MUNC-18a. AA range:279-328 |
| Sequence | |
| Specificity | Unc18-1 Polyclonal Antibody detects endogenous levels of Unc18-1 protein. |
| Gene Name | STXBP1 |
| Protein Name | Syntaxin-binding protein 1 |
| Other Name | STXBP1; / UNC18A; / Syntaxin-binding protein 1; / MUNC18-1; / N-Sec1; / Protein unc-18 homolog 1; / Unc18-1; / Protein unc-18 homolog A; / Unc-18A; / p67 |
| Species | Human |
| Gene ID-1 | 6812 |
| Uniprot | P61764, |
| Species.1 | Mouse |
| Gene ID-2 | 20910 |
| Uniprot.1 | O08599, |
| Species.2 | Rat |
| Gene ID-3 | 25558 |
| Uniprot.2 | P61765 |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010], |
| Cellular Localization | Cytoplasm, cytosol . Membrane; Peripheral membrane protein. |
| Tissue Expression | Brain and spinal cord. Highly enriched in axons. |
| Signaling_pathway | Organismal Systems >> Nervous system >> Synaptic vesicle cycle |
| Research Areas | >>Synaptic vesicle cycle |
| Function | Disease:Defects in STXBP1 are the cause of early infantile epileptic encephalopathy type 4 (EIEE4) [MIM:612164]. Affected individuals have neonatal or infantile onset of seizures, suppression-burst pattern on EEG, profound mental retardation, and MRI evidence of hypomyelination.,Function:May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.,similarity:Belongs to the STXBP/unc-18/SEC1 family.,subunit:Binds SYTL4 and STX1A.,tissue specificity:Brain and spinal cord. Highly enriched in axons., |
| RRID |
