Uroplakin III [ABT523] mouse mAb
Ucallm_WM1493-50
Price range: $268.00 through $328.00
Product details
Background:
Uroplakin III is an asymmetric unit of 47 kDa glycoprotein, which is expressed in the epithelial cells of renal pelvis, ureter, bladder and urinary tract. It is a marker with high specificity and moderate sensitivity for tumors derived from urinary tract epithelial cells. It can be used for the study of tumors of urethral epithelial origin.
Specifications
| Size | 50μL/100μL |
| Target | Uroplakin III |
| Reactivity | Human, Mouse |
| Applications | IHC, WB, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 50-60kD |
| Host Species | Mouse |
| Isotype | IgG1,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1000; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMM523 |
| Immunogen | Synthesized peptide derived from human Uroplakin III AA range: 200-287 |
| Specificity | The antibody can specifically recognize human Uroplakin III protein. |
| Gene Name | UPK3A UPK3 |
| Protein Name | Uroplakin-3a (UP3a) (Uroplakin III) (UPIII) |
| Other Name | MGC119178; / OTTHUMP00000028951; / UP III; / UP3a; / UPIII; / UPIIIA; / UPK 3; / UPK 3A; / UPK3; / UPK3A; / UPK3A_HUMAN; / Uroplakin 3A; / Uroplakin III; / Uroplakin-3a; / Uroplakin3A; / UroplakinIII |
| Species | Human |
| Gene ID | 7380 |
| Uniprot | O75631 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Membranous, Cytoplasmic |
| Tissue Expression | Expressed in ureter. |
| Signaling_pathway | Human Diseases >> Cancer: specific types >> Bladder cancer |
| Research Areas | >>Bladder cancer |
| Function | Disease:Defects in UPK3A are a cause of renal adysplasia [MIM:191830]; also known as renal agenesis or renal aplasia. Renal agenesis refers to the absence of one (unilateral) or both (bilateral) kidneys at birth. Bilateral renal agenesis belongs to a group of perinatally lethal renal diseases, including severe bilateral renal dysplasia, unilateral renal agenesis with contralateral dysplasia and severe obstructive uropathy.,Function:Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence.,similarity:Belongs to the uroplakin-3 family.,subcellular location:Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER).,subunit:Heterodimer with uroplakin-1B (UPK1B).,tissue specificity:Expressed in ureter., |
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