Price range: $268.00 through $328.00
Background:
This gene encodes a portion of the V0 domain of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Activity of this enzyme is necessary for such varied processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014],
| Size | 50μL/100μL |
| Target | VATO |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 23kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human VATO AA range: 149-199 |
| Specificity | This antibody detects endogenous levels of VATO at Human/Mouse |
| Gene Name | ATP6V0B ATP6F |
| Protein Name | VATO |
| Other Name | |
| Species | Human |
| Gene ID | 533 |
| Uniprot | Q99437, |
| Species.1 | Mouse |
| Gene ID.1 | 114143 |
| Uniprot.1 | Q91V37 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasmic vesicle, clathrin-coated vesicle membrane; Multi-pass membrane protein . |
| Tissue Expression | Ubiquitous. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Phagosome;Cellular Processes >> Transport and catabolism >> Lysosome;Organismal Systems >> Nervous system >> Synaptic vesicle cycle;Human Diseases >> Immune disease >> Rheumatoid arthritis |
| Research Areas | >>Oxidative phosphorylation; / >>Metabolic pathways; / >>Lysosome; / >>Phagosome; / >>Synaptic vesicle cycle; / >>Vibrio cholerae infection; / >>Epithelial cell signaling in Helicobacter pylori infection; / >>Tuberculosis; / >>Human papillomavirus infection; / >>Rheumatoid arthritis |
| Function | Function:Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.,similarity:Belongs to the V-ATPase proteolipid subunit family.,tissue specificity:Ubiquitous., |
