VGLU1 rabbit pAb
Ucallm_WP3487-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | VGLUT1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 60kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human VGLU1 AA range: 488-538 |
| Specificity | This antibody detects endogenous levels of VGLU1 at Human/Mouse/Rat |
| Gene Name | SLC17A7 BNPI VGLUT1 |
| Protein Name | Vesicular glutamate transporter 1 |
| Other Name | VGLU1; / Vesicular glutamate transporter 1; / VGluT1; / Brain-specific Na; / +; / -dependent inorganic phosphate cotransporter; / Solute carrier family 17 member 7 |
| Species | Human |
| Gene ID | 57030 |
| Uniprot | Q9P2U7, |
| Species.1 | Mouse |
| Gene ID.1 | 72961 |
| Uniprot.1 | Q3TXX4, |
| Species.2 | Rat |
| Gene ID.2 | 116638 |
| Uniprot.2 | Q62634 |
| Cellular Localization | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane . Membrane; Multi-pass membrane protein . Cell junction, synapse, synaptosome . |
| Tissue Expression | Expressed in several regions of the brain including amygdala, cerebellum, cerebral cortex, hippocampus, frontal lobe, medulla, occipital lobe, putamen and temporal lobe. |
| Signaling_pathway | Organismal Systems >> Nervous system >> Glutamatergic synapse;Organismal Systems >> Nervous system >> Synaptic vesicle cycle |
| Research Areas | >>Synaptic vesicle cycle; / >>Retrograde endocannabinoid signaling; / >>Glutamatergic synapse; / >>Nicotine addiction |
| Function | Function:Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.,similarity:Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.,tissue specificity:Expressed in several regions of the brain including amygdala, cerebellum, cerebral cortex, hippocampus, frontal lobe, medulla, occipital lobe, putamen and temporal lobe., |
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