VMAT2 Polyclonal Antibody
Ucallm_WP2707-50
Price range: $268.00 through $328.00
Product details
Background:
The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).[supplied by OMIM, Jan 2011],
Specifications
| Size | 50μL/100μL |
| Target | VMAT2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 56kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 1-80 |
| Specificity | VMAT2 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | SLC18A2 SVMT VMAT2 |
| Protein Name | Synaptic vesicular amine transporter (Monoamine transporter) (Solute carrier family 18 member 2) (Vesicular amine transporter 2) (VAT2) |
| Other Name | |
| Species | Human |
| Gene ID | 6571 |
| Uniprot | Q05940, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q8BRU6, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q01827 |
| Cellular Localization | Cytoplasmic vesicle membrane; Multi-pass membrane protein. |
| Tissue Expression | Brain,Platelet,Substantia nigra,Testis, |
| Signaling_pathway | Organismal Systems >> Nervous system >> Dopaminergic synapse;Organismal Systems >> Nervous system >> Synaptic vesicle cycle;Human Diseases >> Neurodegenerative disease >> Parkinson disease |
| Research Areas | >>Synaptic vesicle cycle; / >>Serotonergic synapse; / >>Dopaminergic synapse; / >>Parkinson disease; / >>Cocaine addiction; / >>Amphetamine addiction; / >>Alcoholism |
| Function | Function:Involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters. Pumps cytosolic monoamines including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. Requisite for vesicular amine storage prior to secretion via exocytosis.,online information:Vesicular monoamine transporter entry,similarity:Belongs to the major facilitator superfamily. Vesicular transporter family., |
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