WDR36 rabbit pAb
Ucallm_WP3626-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG). [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | WDR36 |
| Reactivity | Human |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 105kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human WDR36 AA range: 607-657 |
| Specificity | This antibody detects endogenous levels of WDR36 at Human |
| Gene Name | WDR36 |
| Protein Name | WDR36 |
| Other Name | WD repeat-containing protein 36; / T-cell activation WD repeat-containing protein; / TA-WDRP |
| Species | Human |
| Gene ID | 134430 |
| Uniprot | Q8NI36 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus, nucleolus . |
| Tissue Expression | Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas. In ocular tissues, strong expression in iris, sclera, ciliary muscle, ciliary body, retina and optic nerve. |
| Signaling_pathway | |
| Research Areas | >>Ribosome biogenesis in eukaryotes |
| Function | Disease:Defects in WDR36 are the cause of primary open angle glaucoma type 1G (GLC1G) [MIM:609887]. Primary open angle glaucoma (POAG) is characterized by a specific pattern of optic nerve and visual field defects. The angle of the anterior chamber of the eye is open, and usually the intraocular pressure is increased. The disease is asymptomatic until the late stages, by which time significant and irreversible optic nerve damage has already taken place.,Function:Involved in T cell activation and highly co-regulated with IL2.,similarity:Contains 9 WD repeats.,tissue specificity:Expressed in heart, placenta, liver, skeletal muscle, kidney and pancreas. In ocular tissues, strong expression in iris, sclera, ciliary muscle, ciliary body, retina and optic nerve., |
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