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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/WIPI2 Rabbit Polyclonal Antibody
SKU: WP5795 Categories: ,

WIPI2 Rabbit Polyclonal Antibody

Ucallm_WP5795-50

Price range: $268.00 through $328.00

SKU: WP5795-100
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Product details

Background:

WD repeat domain, phosphoinositide interacting 2(WIPI2) Homo sapiens WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein-protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI2, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids (Proikas-Cezanne et al., 2004 [PubMed 15602573]).[supplied by OMIM, Mar 2008],

Specifications

Size50μL/100μL
TargetWIPI2
ReactivityHuman, Mouse, Rat
ApplicationsIHC, IF
MW(Calculated)
MW(Observed)49kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:50-300; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenRecombinant Protein of WIPI2
SpecificityThe antibody detects endogenous WIPI2 protein
Gene NameWIPI2 CGI-50
Protein NameWD repeat domain phosphoinositide-interacting protein 2
Other NameWD repeat domain phosphoinositide-interacting protein 2; / WIPI-2; / WIPI49-like protein 2
SpeciesHuman
Gene ID26100
UniprotQ9Y4P8,
Species.1Mouse
Gene ID.174781
Uniprot.1Q80W47,
Species.2Rat
Gene ID.2288498
Uniprot.2Q6AY57
Cellular LocalizationPreautophagosomal structure membrane; Peripheral membrane protein; Cytoplasmic side . Localizes to omegasomes membranes which are endoplasmic reticulum connected structures at the origin of preautophagosomal structures. Enriched at preautophagosomal structure membranes in response to PtdIns3P. .
Tissue ExpressionUbiquitously expressed (at protein level). Highly expressed in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors.
Signaling_pathwayCellular Processes >> Transport and catabolism >> Autophagy - animal;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Huntington disease;Human Diseases >> Neurodegenerative disease >> Spinocerebellar ataxia;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases
Research Areas>>Autophagy - other; / >>Autophagy - animal; / >>Alzheimer disease; / >>Amyotrophic lateral sclerosis; / >>Huntington disease; / >>Spinocerebellar ataxia; / >>Pathways of neurodegeneration - multiple diseases; / >>Shigellosis
Functionsimilarity:Contains 3 WD repeats.,tissue specificity:Ubiquitously expressed. Highly expressed in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors.,
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