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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/WNT11 Polyclonal Antibody
SKU: WP0710 Categories: ,

WNT11 Polyclonal Antibody

Ucallm_WP0710-50

Price range: $268.00 through $328.00

SKU: WP0710-100
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Product details

Background:

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play roles in the development of skeleton, kidney and lung, and is considered to be a plausible candidate gene for High Bone Mass Syndrome. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetWNT11
ReactivityHuman, Mouse
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)38kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human protein . at AA range: 190-270
SpecificityWNT11 Polyclonal Antibody detects endogenous levels of protein.
Gene NameWNT11
Protein NameProtein Wnt-11
Other Name
SpeciesHuman
Gene ID7481
UniprotO96014,
Species.1Mouse
Gene ID.1
Uniprot.1P48615
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationSecreted, extracellular space, extracellular matrix.
Tissue ExpressionExpressed in fetal lung, kidney, adult heart, liver, skeletal muscle, and pancreas.
Signaling_pathwayCellular Processes >> Cellular community - eukaryotes >> Signaling pathways regulating pluripotency of stem cells;Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Hepatocellular carcinoma;Human Diseases >> Cancer: specific types >> Gastric cancer;Human Diseases >> Cancer: specific types >> Basal cell carcinoma;Human Diseases >> Cancer: specific types >> Breast cancer;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases;Environmental Information Processing >> Signal transduction >> Wnt signaling pathway;Environmental Information Processing >> Signal transduction >> Hippo signaling pathway;Environmental Information Processing >> Signal transduction >> mTOR signaling pathway
Research Areas>>mTOR signaling pathway; / >>Wnt signaling pathway; / >>Hippo signaling pathway; / >>Signaling pathways regulating pluripotency of stem cells; / >>Melanogenesis; / >>Cushing syndrome; / >>Alzheimer disease; / >>Pathways of neurodegeneration - multiple diseases; / >>Human papillomavirus infection; / >>Pathways in cancer; / >>Proteoglycans in cancer; / >>Basal cell carcinoma; / >>Breast cancer; / >>Hepatocellular carcinoma; / >>Gastric cancer
FunctionFunction:Ligand for members of the frizzled family of seven transmembrane receptors.,Function:Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters.,similarity:Belongs to the Wnt family.,tissue specificity:Expressed in fetal lung, kidney, adult heart, liver, skeletal muscle, and pancreas.,
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