XDH Polyclonal Antibody
Ucallm_WP1952-50
Price range: $268.00 through $328.00
Product details
Background:
Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. [provided by RefSeq, Jan 2014],
Specifications
| Size | 50μL/100μL |
| Target | XDH |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 146kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | XDH Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | XDH XDHA |
| Protein Name | Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (Xanthine oxidoreductase) (XOR)] |
| Other Name | |
| Species | Human |
| Gene ID | 7498 |
| Uniprot | P47989, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q00519, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P22985 |
| Cellular Localization | Cytoplasm . Peroxisome . Secreted. |
| Tissue Expression | Detected in milk (at protein level). |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Peroxisome |
| Research Areas | >>Purine metabolism; / >>Caffeine metabolism; / >>Drug metabolism - other enzymes; / >>Metabolic pathways; / >>Nucleotide metabolism; / >>Peroxisome |
| Function | Catalytic activity:Hypoxanthine + NAD(+) + H(2)O = xanthine + NADH.,Catalytic activity:Xanthine + H(2)O + O(2) = urate + H(2)O(2).,Catalytic activity:Xanthine + NAD(+) + H(2)O = urate + NADH.,cofactor:Binds 2 2Fe-2S clusters.,cofactor:FAD.,cofactor:Molybdopterin.,Disease:Defects in XDH are the cause of xanthinuria type 1 (XU1) [MIM:278300]. Xanthinuria is characterized by excretion of very large amounts of xanthine in the urine and a tendency to form xanthine stones. Uric acid is strikingly diminished in serum and urine. XU1 is due to isolated xanthine dehydrogenase. XU1 patients can metabolize allopurinol.,Disease:May contribute to adult respiratory stress syndrome (ARDS) and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.,Function:This enzyme can be converted from the dehydrogenase form (D) to the oxidase form (O) irreversibly by proteolysis or reversibly through the oxidation of sulfhydryl groups.,similarity:Belongs to the xanthine dehydrogenase family.,similarity:Contains 1 2Fe-2S ferredoxin-type domain.,similarity:Contains 1 FAD-binding PCMH-type domain.,subunit:Homodimer. Interacts with BTN1A1., |
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