Product details
Background:
XLF rabbit pAb
Ucallm_WP6474-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | NHEJ1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 33kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human XLF |
| Specificity | This antibody detects endogenous levels of XLF at Human, Mouse,Rat |
| Gene Name | NHEJ1 XLF |
| Protein Name | Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor) |
| Other Name | |
| Species | Human |
| Gene ID | 79840 |
| Uniprot | Q9H9Q4, |
| Species.1 | Mouse |
| Gene ID.1 | 75570 |
| Uniprot.1 | Q3KNJ2, |
| Species.2 | Rat |
| Gene ID.2 | 363251 |
| Uniprot.2 | Q6AYI4 |
| Cellular Localization | Nucleus . Chromosome . Localizes to site of double-strand breaks; recruitment is dependent on XRCC5-XRCC6 (Ku) heterodimer. . |
| Tissue Expression | Ubiquitously expressed. |
| Signaling_pathway | |
| Research Areas | |
| Function | DNA repair protein involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination . Plays a key role in NHEJ by promoting the ligation of various mismatched and non-cohesive ends . Together with PAXX, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends . May act in concert with XRCC5-XRCC6 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are non-complementary or partially complementary . Associates with XRCC4 to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired . The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other . The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors . Binds DNA in a length-dependent manner . |
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