Name: U-Blot® YAP Rabbit mAb
SKU: WR4304
Price: 268 USD
Availability: InStock

U-Blot® YAP Rabbit mAb

Western blot analysis of lysates from MCF7 cells, using YAP Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002,) was used to detect the antibody.

WR4304 Western blot analysis of lysates from MCF7 cells, using YAP Rabbit mAb. The HRP-conjugated Goat anti-Rabbit IgG antibody (WS0002,) was used to detect the antibody.

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WR4304-50

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Product details

Background:This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013],

Specifications

Target	YAP
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)	55kD
MW(Observed)	55-75kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	IHC 1:100-1:500; WB 1:500-1:2000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	PT0504R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Sequence
Specificity	Endogenous
Gene Name	YAP1
Protein Name	Yorkie homolog
Other Name	YAP1; / YAP65; / Yorkie homolog; / 65 kDa Yes-associated protein; / YAP65
Species	Human
Gene ID-1	10413
Uniprot	P46937,
Species.1	Mouse
Gene ID-2	22601
Uniprot.1	P46938,
Species.2	Rat
Gene ID-3	363014
Uniprot.2	Q2EJA0
Organism-4
Gene ID-4
SwissProt-4
Background	This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013],
Cellular Localization	Cytoplasm, Nucleus
Tissue Expression	Increased expression seen in some liver and prostate cancers. Isoforms lacking the transactivation domain found in striatal neurons of patients with Huntington disease (at protein level).
Signaling_pathway	Environmental Information Processing >> Signal transduction >> Hippo signaling pathway;Environmental Information Processing >> Signal transduction >> Hippo signaling pathway - multiple species
Research Areas	>>Hippo signaling pathway; / >>Hippo signaling pathway - multiple species
Function	PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 WW domain.,subunit:Binds to the SH3 domain of the YES kinase. Binds to WBP1 and WBP2. Binds, in vitro, through the WW1 domain, to neural isoforms of ENAH that contain the PPSY motif.,
RRID