ZAC1 Polyclonal Antibody
Ucallm_WP15037-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015],
Specifications
| Size | 50μL/100μL |
| Target | ZAC1 |
| Reactivity | Human |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 50kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human PLAGL1. AA range:311-360 |
| Specificity | ZAC1 Polyclonal Antibody detects endogenous levels of ZAC1 protein. |
| Gene Name | PLAGL1 |
| Protein Name | Zinc finger protein PLAGL1 |
| Other Name | PLAGL1; / LOT1; / ZAC; / Zinc finger protein PLAGL1; / Lost on transformation 1; / LOT-1; / Pleiomorphic adenoma-like protein 1; / Tumor supressor ZAC |
| Species | Human |
| Gene ID | 5325 |
| Uniprot | Q9UM63 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . |
| Tissue Expression | Colon,Fetal kidney,Lung,Mammary gland,Pituitary,Placenta, |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Shows weak transcriptional activatory activity. Transcriptional regulator of the type 1 receptor for pituitary adenylate cyclase-activating polypeptide.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 7 C2H2-type zinc fingers., |
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