Product details
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ZBTB48 rabbit pAb
Ucallm_WP7297-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | ZBTB48 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 76kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ZBTB48 |
| Specificity | This antibody detects endogenous levels of ZBTB48 at Human, Mouse |
| Gene Name | ZBTB48 HKR3 ZNF855 |
| Protein Name | Zinc finger and BTB domain-containing protein 48 (Krueppel-related zinc finger protein 3) (Protein HKR3) (Zinc finger protein 855) |
| Other Name | |
| Species | Human |
| Gene ID | 3104 |
| Uniprot | P10074, |
| Species.1 | Mouse |
| Gene ID.1 | 100090 |
| Uniprot.1 | Q1H9T6 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Chromosome, telomere . Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411). According to a report, preferentially binds to long telomeres that have a low concentration of shelterin complex, competing with the telomeric repeat binding factors TERF1 and TERF2 (PubMed:28082411). According to another report, binds telomeres regardless of their length (PubMed:28500257). . |
| Tissue Expression | Detected in adrenal gland and neuroblastoma. |
| Signaling_pathway | |
| Research Areas | |
| Function | Telomere-binding protein that acts as a regulator of telomere length . Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat . Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres . Also acts as a transcription regulator that binds to promoter regions . Regulates expression of a small subset of genes, including MTFP1 . Regulates expression the J and/or S elements in MHC II promoter . Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A . |
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