Price range: $268.00 through $328.00
Background:
This gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein may function as a palmitoyltransferase. Defects in this gene may be associated with a susceptibility to schizophrenia. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 22.[provided by RefSeq, May 2010],
| Size | 50μL/100μL |
| Target | ZDHC8 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 85kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ZDHC8 AA range: 289-339 |
| Specificity | This antibody detects endogenous levels of ZDHC8 at Human/Mouse |
| Gene Name | ZDHHC8 KIAA1292 ZDHHCL1 ZNF378 |
| Protein Name | ZDHC8 |
| Other Name | Probable palmitoyltransferase ZDHHC8; / Zinc finger DHHC domain-containing protein 8; / DHHC-8; / Zinc finger protein 378 |
| Species | Human |
| Gene ID | 29801 |
| Uniprot | Q9ULC8, |
| Species.1 | Mouse |
| Gene ID.1 | 27801 |
| Uniprot.1 | Q5Y5T5 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Golgi apparatus membrane; Multi-pass membrane protein . Mitochondrion membrane; Multi-pass membrane protein . |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.,Disease:According to PubMed:15489219 and PubMed:15184899, defects in ZDHHC8 may contribute to susceptibility to schizophrenia, but according to PubMed:15992527, PubMed:15631889 and PubMed:16150541, it is not the case.,Domain:The DHHC domain is required for palmitoyltransferase activity.,Function:Putative palmitoyltransferase involved in glutamatergic transmission.,similarity:Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.,similarity:Contains 1 DHHC-type zinc finger., |
