Price range: $268.00 through $328.00
Background:
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | ZHX2 |
| Reactivity | Human, Mouse |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 92kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ZHX2. AA range:751-800 |
| Specificity | ZHX2 Polyclonal Antibody detects endogenous levels of ZHX2 protein. |
| Gene Name | ZHX2 |
| Protein Name | Zinc fingers and homeoboxes protein 2 |
| Other Name | ZHX2; / AFR1; / KIAA0854; / RAF; / Zinc fingers and homeoboxes protein 2; / Alpha-fetoprotein regulator 1; / AFP regulator 1; / Regulator of AFP; / Zinc finger and homeodomain protein 2 |
| Species | Human |
| Gene ID | 22882 |
| Uniprot | Q9Y6X8, |
| Species.1 | Mouse |
| Gene ID.1 | 387609 |
| Uniprot.1 | Q8C0C0 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Colocalizes with EFNB1 intracellular domain in the nucleus. . |
| Tissue Expression | Ubiquitously expressed. Expressed in podocytes. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Acts as a transcriptional repressor.,similarity:Belongs to the ZHX family.,similarity:Contains 2 C2H2-type zinc fingers.,similarity:Contains 4 homeobox DNA-binding domains.,subunit:Forms homodimers. Also forms heterodimers with ZHX1 and ZHX3. Heterodimerization with ZHX1 is not necessary for repressor activity. Interacts with NFYA.,tissue specificity:Ubiquitously expressed., |
