Name: Zic1/2/3 Polyclonal Antibody
SKU: WP15052
Price: 268 USD
Availability: InStock

Zic1/2/3 Polyclonal Antibody

Ucallm_WP15052-50

Price range: $268.00 through $328.00

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50μl

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SKU: WP15052-100

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Product details

Background:

This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008],

Specifications

Target	Zic1/2/3
Reactivity	Human, Mouse
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	51kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human ZIC1/2/3. AA range:316-365
Sequence
Specificity	Zic1/2/3 Polyclonal Antibody detects endogenous levels of Zic1/2/3 protein.
Gene Name	ZIC1/ZIC2/ZIC3
Protein Name	Zinc finger protein ZIC 1
Other Name	ZIC1; / ZIC; / ZNF201; / Zinc finger protein ZIC 1; / Zinc finger protein 201; / Zinc finger protein of the cerebellum 1; / ZIC2; / Zinc finger protein ZIC 2; / Zinc finger protein of the cerebellum 2; / ZIC3; / ZNF203; / Zinc finger protein ZIC 3; / Zinc finger p
Species	Human
Gene ID-1	7545;7546;7547
Uniprot	Q15915;O95409;O60481,
Species.1	Mouse
Gene ID-2	22771;22773
Uniprot.1
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background	This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. Members of this family are important during development. Aberrant expression of this gene is seen in medulloblastoma, a childhood brain tumor. This gene is closely linked to the gene encoding zinc finger protein of the cerebellum 4, a related family member on chromosome 3. This gene encodes a transcription factor that can bind and transactivate the apolipoprotein E gene. [provided by RefSeq, Jul 2008],
Cellular Localization	Nucleus. Cytoplasm . Localizes in the cytoplasm in presence of MDFIC overexpression. .
Tissue Expression	CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined.
Signaling_pathway	Cellular Processes >> Cellular community - eukaryotes >> Signaling pathways regulating pluripotency of stem cells
Research Areas
Function	Function:May play a role in cerebellar development.,similarity:Belongs to the GLI C2H2-type zinc-finger protein family.,similarity:Contains 5 C2H2-type zinc fingers.,tissue specificity:CNS. A high level expression is seen in the cerebellum. Detected in the nuclei of the cerebellar granule cell lineage from the progenitor cells of the external germinal layer to the postmigrated cells of the internal granular layer. Detected in medulloblastoma (26/29 cases), but not present in all other tumors examined.,
RRID

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Zic1/2/3 Polyclonal Antibody

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Specifications

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Zic1/2/3 Polyclonal Antibody

Product details

Specifications

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