Price range: $268.00 through $328.00
Background:
ZMIZ2 and ZMIZ1 (MIM 607159) are members of a PIAS (see MIM 603566)-like family of proteins that interact with nuclear hormone receptors. ZMIZ2 interacts with androgen receptor (AR; MIM 313700) and enhances AR-mediated transcription (Huang et al., 2005 [PubMed 16051670]).[supplied by OMIM, May 2010],
| Size | 50μL/100μL |
| Target | ZMIZ2 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 101kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ZMIZ2 AA range: 512-562 |
| Specificity | This antibody detects endogenous levels of ZMIZ2 at Human/Mouse |
| Gene Name | ZMIZ2 KIAA1886 ZIMP7 HRIHFB2007 |
| Protein Name | ZMIZ2 |
| Other Name | |
| Species | Human |
| Gene ID | 83637 |
| Uniprot | Q8NF64, |
| Species.1 | Mouse |
| Gene ID.1 | 52915 |
| Uniprot.1 | Q8CIE2 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . Detected at replication foci throughout S phase. |
| Tissue Expression | Expressed most abundantly in testis with lower levels in heart, brain, pancreas, prostate and ovary. |
| Signaling_pathway | |
| Research Areas | |
| Function | Domain:The C-terminal proline-rich domain possesses a significant intrinsic transcriptional activity. This activity is inhibited by the N-terminus in the full-length protein.,Function:Increases ligand-dependent transcriptional activity of AR and other nuclear hormone receptors.,similarity:Contains 1 SP-RING-type zinc finger.,subcellular location:Detected at replication foci throughout S phase.,subunit:Interacts with AR, SMARCA4/BRG1 and SMARCE1/BAF57. Interaction with either SMARCA4 and SMARCE1 enhances AR-mediated transcription.,tissue specificity:Expressed most abundantly in testis with lower levels in heart, brain, pancreas, prostate and ovary., |
