Product details
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ZNF385A rabbit pAb
Ucallm_WP8652-50
Price range: $268.00 through $328.00
Specifications
| Target | ZNF385A |
| Reactivity | Human |
| Applications | WB |
| MW(Calculated) | 42kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ZNF385A |
| Sequence | |
| Specificity | This antibody detects endogenous levels of ZNF385A at Human |
| Gene Name | ZNF385A HZF RZF ZNF385 |
| Protein Name | Zinc finger protein 385A (Hematopoietic zinc finger protein) (Retinal zinc finger protein) |
| Other Name | |
| Species | Human |
| Gene ID-1 | 25946 |
| Uniprot | Q96PM9 |
| Species.1 | |
| Gene ID-2 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID-3 | |
| Uniprot.2 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | |
| Cellular Localization | Cytoplasm . Nucleus, nucleolus . Cell projection, dendrite . Detected in dendrites of Purkinje cells and hippocampal neurons. . |
| Tissue Expression | Expressed predominantly in the retina. |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> p53 signaling pathway |
| Research Areas | |
| Function | RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation. |
| RRID |
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