ZW10 rabbit pAb
Ucallm_WP16833-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. [provided by RefSeq, Aug 2011],
Specifications
| Size | 50μL/100μL |
| Target | ZW10 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 86kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ZW10 AA range: 38-88 |
| Specificity | This antibody detects endogenous levels of ZW10 at Human/Mouse/Rat |
| Gene Name | ZW10 |
| Protein Name | ZW10 |
| Other Name | |
| Species | Human |
| Gene ID | 9183 |
| Uniprot | O43264, |
| Species.1 | Mouse |
| Gene ID.1 | 26951 |
| Uniprot.1 | O54692, |
| Species.2 | Rat |
| Gene ID.2 | 363059 |
| Uniprot.2 | Q4V8C2 |
| Cellular Localization | Cytoplasm . Endoplasmic reticulum membrane; Peripheral membrane protein . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle . Lipid droplet . Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm (PubMed:15029241). In prometaphase, associated with the kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and telophase, accumulates at the spindle midzone (PubMed:11590237). . |
| Tissue Expression | Widely expressed. |
| Signaling_pathway | |
| Research Areas | |
| Function | developmental stage:No significant variation in expression during cell cycle.,Function:Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum.,miscellaneous:Overexpression as well as silencing of ZW10 disrupts the morphology of the ER-Golgi intermediate compartment as well as the Golgi apparatus and slows down ER-Golgi transport.,similarity:Belongs to the ZW10 family.,subcellular location:Dynamic pattern of localization during the cell cycle. In most cells at interphase, present diffusely in the cytoplasm. In prometaphase, associated with the kinetochore. At metaphase, detected both at the kinetochores and, most prominently, at the spindle, particularly at the spindle poles. In very early anaphase, detected on segregating kinetochores. In late anaphase and telophase, accumulates at the spindle midzone.,subunit:Associated with a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L, and SEC22B through direct interaction with RINT1/TIP20L bound to BNIP1/SEC20L. Component of the RZZ complex composed of KNTC1/ROD, ZW10 and ZWILCH. Interacts with C19orf25, KNTC1, and ZWINT.,tissue specificity:Widely expressed., |
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