Name: U-Blot® TERF2 Rabbit mAb
SKU: WR5283
Price: 268 USD
Availability: InStock

U-Blot® TERF2 Rabbit mAb

Ucallm_WR5283-50

Price range: $268.00 through $328.00

Size

100μl

50μl

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SKU: WR5283-100

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Product details

Background:This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	TRF2
Reactivity	Human
Applications	WB, IHC, IF, ELISA
MW(Calculated)	60kD
MW(Observed)	65kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:500-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM1537R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	TERF2 TRBF2 TRF2
Protein Name	Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein)
Other Name	Telomeric repeat-binding factor 2; / TTAGGG repeat-binding factor 2; / Telomeric DNA-binding protein
Species	Human
Gene ID	7014
Uniprot	Q15554,
Species.1	Mouse
Gene ID.1	21750
Uniprot.1	O35144
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Nucleus . Chromosome, telomere . Colocalizes with telomeric DNA in interphase cells and is located at chromosome ends during metaphase.
Tissue Expression	Ubiquitous. Highly expressed in spleen, thymus, prostate, uterus, testis, small intestine, colon and peripheral blood leukocytes.
Signaling_pathway
Research Areas
Function	Function:Binds the telomeric double-stranded TTAGGG repeat. Protects against end-to-end fusion of chromosomes and plays a role in successful progression through the cell division cycle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 HTH myb-type DNA-binding domain.,subcellular location:Colocalizes with telomeric DNA in interphase cells and is located at chromosome ends during metaphase.,subunit:Homodimer. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Binds to RAP1. Interacts with NBN.,tissue specificity:Ubiquitous. Highly expressed in spleen, thymus, prostate, uterus, testis, small intestine, colon and peripheral blood leukocytes.,