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Background:This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008],
| Target | GRK1 |
| Reactivity | Human,Mouse,Rat |
| Applications | WB,IF,ELISA |
| MW(Calculated) | 64kD |
| MW(Observed) | 64kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000; |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Source | |
| Purification | Protein A |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Clonality | Monoclonal |
| Clone Number | PT1673R |
| Specificity | Endogenous |
| Gene Name | GRK1 |
| Protein Name | Rhodopsin kinase |
| Other Name | GRK1;RHOK;Rhodopsin kinase;RK;G protein-coupled receptor kinase 1 |
| Organism-1 | Human |
| Gene ID-1 | 6011 |
| SwissProt-1 | Q15835 |
| Organism-2 | Mouse |
| Gene ID-2 | |
| SwissProt-2 | Q9WVL4 |
| Organism-3 | Rat |
| Gene ID-3 | 81760 |
| SwissProt-3 | Q63651 |
| Function | Catalytic activity:ATP + [rhodopsin] = ADP + [rhodopsin] phosphate.,Disease:Defects in GRK1 are a cause of congenital stationary night blindness Oguchi type (CSNBO) [MIM:258100]; also known as Oguchi disease. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. CSNBO is an autosomal recessive form associated with fundus discoloration and abnormally slow dark adaptation.,Function:Phosphorylates rhodopsin thereby initiating its deactivation.,online information:Retina International's Scientific Newsletter,PTM:Autophosphorylated.,PTM:Farnesylation is required for full activity.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 RGS domain.,tissue specificity:Retina and pineal gland., |
| Cellular Localization | Membrane ; Lipid-anchor . Cell projection, cilium, photoreceptor outer segment . Subcellular location is not affected by light or dark conditions. . |
| Tissue Expression | Retinal-specific. Expressed in rods and cones cells. |
| Unnamed: 31 | |
| SwissProt-3.1 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Cellular Localization.1 |
