Name: U-Blot® p90RSK Rabbit mAb
SKU: WR4212
Price: 268 USD
Availability: InStock

U-Blot® p90RSK Rabbit mAb

Hela whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with primary antibody(1:1000). The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody.

WR4212 Hela whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with primary antibody(1:1000). The HRP-conjugated Goat anti-Rabbit IgG(H + L) antibody was used to detect the antibody.

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WR4212-50

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Product details

Background:Ribosomal protein S6 kinase A1(RPS6KA1) Homo sapiens This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	Rsk-1
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, IP, ELISA
MW(Calculated)	83kD
MW(Observed)	83kD
Host Species	Rabbit
Isotype	IgG,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:2000-1:5000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM0822R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	RPS6KA1 MAPKAPK1A RSK1
Protein Name	Ribosomal protein S6 kinase alpha-1
Other Name	RPS6KA1; / MAPKAPK1A; / RSK1; / Ribosomal protein S6 kinase alpha-1; / S6K-alpha-1; / 90 kDa ribosomal protein S6 kinase 1; / p90-RSK 1; / p90RSK1; / p90S6K; / MAP kinase-activated protein kinase 1a; / MAPK-activated protein kinase 1a; / MAPKAP kinase 1a; / MAPKAP
Species	Human
Gene ID	6195
Uniprot	Q15418,
Species.1	Mouse
Gene ID.1
Uniprot.1	P18653,
Species.2	Rat
Gene ID.2	81771
Uniprot.2	Q63531
Cellular Localization	Cytoplasm,Nucleus
Tissue Expression	Colon,Epithelium,
Signaling_pathway	Organismal Systems >> Nervous system >> Neurotrophin signaling pathway;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> mTOR signaling pathway
Research Areas	>>MAPK signaling pathway; / >>Oocyte meiosis; / >>mTOR signaling pathway; / >>Thermogenesis; / >>Long-term potentiation; / >>Neurotrophin signaling pathway; / >>Progesterone-mediated oocyte maturation; / >>Insulin resistance; / >>Yersinia infection; / >>Chemical carcinogenesis - receptor activation
Function	Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,Caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,cofactor:Magnesium.,enzyme regulation:Activated by multiple phosphorylations on threonine and serine residues.,Function:Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB.,PTM:Autophosphorylated on Ser-380, as part of the activation process.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 2 protein kinase domains.,subunit:Forms a complex with either ERK1 or ERK2 in quiescent cells. Transiently dissociates following mitogenic stimulation.,