Name: Cytokeratin 7 [ABT319] mouse mAb
SKU: WM1606
Price: 268 USD
Availability: InStock

Cytokeratin 7 [ABT319] mouse mAb

Ucallm_WM1606-50

Price range: $268.00 through $328.00

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50μl

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SKU: WM1606-50

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Product details

Background:
keratin 7(KRT7) Homo sapiens The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	Cytokeratin 7
Reactivity	Human
Applications	IHC, ELISA
MW(Calculated)	51kD
MW(Observed)	51kD
Host Species	Mouse
Isotype	IgG1,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-400; ELISA 1:500-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RMM319
Immunogen	Synthesized peptide derived from human Cytokeratin 7 AA range: 350-469
Specificity	The antibody can specifically recognize human CK7 protein, and shows no cross reaction with CK1, 4, 5, 6, 8, 10, 14, 17, 18, 19, 20.
Gene Name	KRT7 SCL
Protein Name	CK 7; CK-7; CK7; Cytokeratin 7; Cytokeratin-7; D15Wsu77e; K2C7; K2C7_HUMAN; K7; Keratin 7; Keratin 7, type II; Keratin type II cytoskeletal 7; Keratin, 55K type II cytoskeletal; Keratin, simple epithelial; Keratin, simple epithelial type I, K7; Keratin, type II cytoskeletal 7; Keratin-7; Krt2-7; KRT7; MGC11625; MGC129731; MGC3625; Sarcolectin; SCL; Type II mesothelial keratin K7; Type-II keratin Kb7
Other Name	CK 7; / CK-7; / CK7; / Cytokeratin 7; / Cytokeratin-7; / D15Wsu77e; / K2C7; / K2C7_HUMAN; / K7; / Keratin 7; / Keratin 7, type II; / Keratin type II cytoskeletal 7; / Keratin, 55K type II cytoskeletal; / Keratin, simple epithelial; / Keratin, simple epithelial type I, K7; / Keratin, type II cytoskeletal 7; / Keratin-7; / Krt2-7; / KRT7; / MGC11625; / MGC129731; / MGC3625; / Sarcolectin; / SCL; / Type II mesothelial keratin K7; / Type-II keratin Kb7
Species	Human
Gene ID	3855
Uniprot	P08729
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasmic, Membranous
Tissue Expression	Pancreas
Signaling_pathway
Research Areas
Function	Function:Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).,induction:Up-regulated by retinoic acid.,mass spectrometry: PubMed:11840567,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,PTM:Arg-20 is dimethylated, probably to asymmetric dimethylarginine.,similarity:Belongs to the intermediate filament family.,subunit:Heterotetramer of two type I and two type II keratins. Interacts with eukaryotic translation initiator factor 3 (eIF3) subunit EIF3S10 and with HPV16 E7.,tissue specificity:Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver. Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the esophagus.,

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Cytokeratin 7 [ABT319] mouse mAb

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Cytokeratin 7 [ABT319] mouse mAb

Product details

Specifications

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