SKU: WM1350 Categories: ,

CRHR2 [PTR1205] mouse mAb

Price range: $268.00 through $328.00

SKU: WM1350-50
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Product details

Background:
corticotropin releasing hormone receptor 2(CRHR2) Homo sapiens The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011],

Specifications

Size50μL/100μL
TargetCRHR2
ReactivityHuman, Mouse, Rat
ApplicationsWB, IF, ELISA
MW(Calculated)47kD
MW(Observed)47kD
Host SpeciesMouse
IsotypeIgG2b,Kappa
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000
FormulationPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
PurificationRecombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityMonoclonal
Clone NumberRMMR1205
ImmunogenSynthesized peptide derived from human CRHR2 AA range: 50-150
SpecificityThis antibody detects endogenous levels of CRHR2 protein.
Gene NameCRHR2 CRF2R CRH2R
Protein NameCorticotropin-releasing factor receptor 2
Other NameCRHR2; / CRF2R; / CRH2R; / Corticotropin-releasing factor receptor 2; / CRF-R-2; / CRF-R2; / CRFR-2; / Corticotropin-releasing hormone receptor 2; / CRH-R-2; / CRH-R2
SpeciesHuman
Gene ID1395
UniprotQ13324,
Species.1Mouse
Gene ID.1
Uniprot.1Q60748,
Species.2Rat
Gene ID.264680
Uniprot.2P47866
Cellular Localization
Tissue Expression
Signaling_pathwayEnvironmental Information Processing >> Signal transduction >> cAMP signaling pathway
Research Areas
FunctionG-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.
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