Price range: $268.00 through $328.00
Background:
This gene encodes a beta tubulin protein. This protein forms a dimer with alpha tubulin and acts as a structural component of microtubules. Mutations in this gene cause cortical dysplasia, complex, with other brain malformations 6. Alternative splicing results in multiple splice variants. There are multiple pseudogenes for this gene on chromosomes 1, 6, 7, 8, 9, and 13. [provided by RefSeq, Jun 2014],
| Size | 50μL/100μL |
| Target | Tubulin β |
| Reactivity | Human, Mouse, Rat, Pig |
| Applications | WB, IF, ELISA |
| MW(Calculated) | 50kD |
| MW(Observed) | 50kD |
| Host Species | Mouse |
| Isotype | IgG1,kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000; |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RMMR1389 |
| Immunogen | AA range: 400-500 |
| Specificity | This antibody detects endogenous levels of Beta Tubulin protein. |
| Gene Name | TUBB |
| Protein Name | Tubulin beta chain (Tubulin beta-5 chain) |
| Other Name | Tubulin beta chain (Tubulin beta-5 chain) |
| Species | Human |
| Gene ID | 203068 |
| Uniprot | P07437, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P99024, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P69897 |
| Cellular Localization | Cytoplasm |
| Tissue Expression | Ubiquitously expressed with highest levels in spleen, thymus and immature brain. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Phagosome;Cellular Processes >> Cellular community - eukaryotes >> Gap junction;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Parkinson disease;Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Huntington disease;Human Diseases >> Neurodegenerative disease >> Prion disease;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases |
| Research Areas | >>Phagosome; / >>Gap junction; / >>Alzheimer disease; / >>Parkinson disease; / >>Amyotrophic lateral sclerosis; / >>Huntington disease; / >>Prion disease; / >>Pathways of neurodegeneration - multiple diseases; / >>Pathogenic Escherichia coli infection; / >>Salmonella infection |
| Function | Domain:The highly acidic C-terminal region may bind cations such as calcium.,Function:Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.,online information:Tubulin entry,similarity:Belongs to the tubulin family.,subunit:Dimer of alpha and beta chains.,tissue specificity:Ubiquitously expressed with highest levels in spleen, thymus and immature brain., |
