Price range: $268.00 through $328.00
Background:
This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | ITK |
| Reactivity | Human |
| Applications | WB, IF, FC, ELISA |
| MW(Calculated) | 72kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IF 1:200-1:1000; Flow Cyt 1:200-1:400; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 3C9 |
| Immunogen | Purified recombinant fragment of human Emt expressed in E. Coli. |
| Specificity | Emt Monoclonal Antibody detects endogenous levels of Emt protein. |
| Gene Name | ITK EMT LYK |
| Protein Name | Tyrosine-protein kinase ITK/TSK |
| Other Name | ITK; / EMT; / LYK; / Tyrosine-protein kinase ITK/TSK; / Interleukin-2-inducible T-cell kinase; / IL-2-inducible T-cell kinase; / Kinase EMT; / T-cell-specific kinase; / Tyrosine-protein kinase Lyk |
| Species | Human |
| Gene ID | 3702 |
| Uniprot | Q08881 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Nucleus . Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation. |
| Tissue Expression | T-cell lines and natural killer cell lines. |
| Signaling_pathway | Organismal Systems >> Immune system >> T cell receptor signaling pathway;Organismal Systems >> Immune system >> Leukocyte transendothelial migration;Organismal Systems >> Immune system >> Chemokine signaling pathway |
| Research Areas | >>Chemokine signaling pathway; / >>T cell receptor signaling pathway; / >>Leukocyte transendothelial migration |
| Function | Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,cofactor:Binds 1 zinc ion per subunit.,Function:Plays a role in T-cell proliferation and differentiation.,induction:By interleukin-2.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.,similarity:Contains 1 Btk-type zinc finger.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subcellular location:Localizes to cell surface receptors in the plasma membrane after stimulation with respective receptors (TCR, CD28, CD2) in T-cells.,tissue specificity:T-cell lines and natural killer cell lines., |
