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Background:This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins.This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations inThis gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]

Specifications

Size	100μL
Target	CD326/EPCAM
Reactivity	Human
Applications	ELISA
MW(Calculated)
MW(Observed)
Host Species
Isotype	IgG2a,Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	ELISA 1:5000-100000; Flow Cyt 1-2μg/Test
Formulation	Phosphate-buffered solution
Purification	Recombinant Expression and Affinity purified
Storage	-15°C to -25°C/1 year(Avoid freeze / thaw cycles)
Concentration	Please check the information on the tube
Clonality
Clone Number	VF0613
Immunogen	Purified recombinant Human CD326
Specificity	This recombinant monoclonal antibody can detects endogenous levels of CD326/EPCAM protein.
Gene Name	EPCAM GA733-2 M1S2 M4S1 MIC18 TACSTD1 TROP1
Protein Name	Epithelial cell adhesion molecule
Other Name	17 1A; / 323/A3; / Adenocarcinoma associated antigen; / Adenocarcinoma-associated antigen; / Antigen identified by monoclonal antibody AUA1; / AUA1; / CD326; / CD326 antigen; / Cell surface glycoprotein Trop 1; / Cell surface glycoprotein Trop 2; / Cell surface glycoprotein Trop-1; / CO 17A; / CO17 1A; / CO17A; / DIAR5; / EGP 2; / EGP; / EGP2; / EGP314; / EGP40; / Ep CAM; / Ep-CAM; / EPCAM; / EPCAM_HUMAN; / Epithelial cell adhesion molecule; / Epithelial Cell Adhesion Molecule Intracellular Domain; / EpCAM-ICD; / Epithelial cell surface antigen; / Epithelial cellular adhesion molecule; / Epithelial glycoprotein 1; / Epithelial glycoprotein 314; / Epithelial glycoprotein; / ESA; / GA733 1; / GA733 2; / GA733-2; / gastrointestinal tumor-associated antigen 2; / 35-KD glycoprotein; / hEGP 2; / hEGP314; / HNPCC8; / Human epithelial glycoprotein 2; / KS 1/4 antigen; / KS1/4; / KSA; / Lymphocyte antigen 74; / M1S 1; / M1S2; / M4S1; / Major gastrointestinal tumor associated protein GA733 2; / Major gastrointestinal tumor-associated protein GA733-2; / Membrane component chromosome 4 surface marker; / 35kD glycoprotein; / Membrane component; / chromosome 4; / surface marker 1; / Membrane component; / chromosome 4; / surface marker; / MIC18; / MK 1; / TACD1; / TACSTD1; / TROP1; / Tumor associated calcium signal transducer 1; / Tumor associated calcium signal transducer 2 precursor; / Tumor-associated calcium signal transducer 1; / CD326 nanobody; / EPCAM nanobody
Species	Human
Gene ID	4072
Uniprot	P16422
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Lateral cell membrane; Single-pass type I membrane protein . Cell junction, tight junction . Colocalizes with CLDN7 at the lateral cell membrane and tight junction. .
Tissue Expression	Monocytic/myeloid lineage cells. In the brain, CD33 is mainly expressed on microglial cells.
Signaling_pathway
Research Areas
Function	Domain:Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).,online information:Siglec-3,PTM:Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6.,similarity:Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation.,tissue specificity:Monocytic/myeloid lineage cells.,

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Recombinant CD326/EPCAM Fc-Fused Nanobody (VF0561)

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Recombinant CD326/EPCAM Fc-Fused Nanobody (VF0561)

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