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Background：
This gene encodes a member of the uroplakin family, a group of transmembrane proteins that form complexes on the apical surface of the bladder epithelium. Mutations in this gene may be associated with renal adysplasia. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009],
| Size | 6mL |
| Target | UPK3A |
| Reactivity | Human, Mouse |
| Applications | IHC |
| MW(Calculated) | |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG1,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | Ready to use for IHC / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300 |
| Purification | Recombinant Expression and Affinity purified |
| Storage | 2°C to 8°C/1 year,Ship by ice bag |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM72R |
| Immunogen | Synthesized peptide derived from human protein . at AA range:200-287 |
| Specificity | This antibody detects endogenous levels of UPK3A |
| Gene Name | UPK3A |
| Protein Name | Uroplakin-3a (UP3a) (Uroplakin III) (UPIII) |
| Other Name | MGC119178; / OTTHUMP00000028951; / UP III; / UP3a; / UPIII; / UPIIIA; / UPK 3; / UPK 3A; / UPK3; / UPK3A; / UPK3A_HUMAN; / Uroplakin 3A; / Uroplakin III; / Uroplakin-3a; / Uroplakin3A; / UroplakinIII |
| Species | Human |
| Gene ID | 7380 |
| Uniprot | O75631, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9JKX8 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Endoplasmic reticulum membrane; Single-pass type I membrane protein . Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER). . |
| Tissue Expression | Expressed in ureter. |
| Signaling_pathway | Human Diseases >> Cancer: specific types >> Bladder cancer |
| Research Areas | >>Bladder cancer |
| Function | Disease:Defects in UPK3A are a cause of renal adysplasia [MIM:191830]; also known as renal agenesis or renal aplasia. Renal agenesis refers to the absence of one (unilateral) or both (bilateral) kidneys at birth. Bilateral renal agenesis belongs to a group of perinatally lethal renal diseases, including severe bilateral renal dysplasia, unilateral renal agenesis with contralateral dysplasia and severe obstructive uropathy.,Function:Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in AUM-cytoskeleton interaction in terminally differentiated urothelial cells. It also contributes to the formation of urothelial glycocalyx which may play an important role in preventing bacterial adherence.,similarity:Belongs to the uroplakin-3 family.,subcellular location:Heterodimer formation with UPK1B is a prerequisite to exit out of the endoplasmic reticulum (ER).,subunit:Heterodimer with uroplakin-1B (UPK1B).,tissue specificity:Expressed in ureter., |
