Name: U-Blot® CD3 Rabbit mAb
SKU: WR6097
Price: 268 USD
Availability: InStock

U-Blot® CD3 Rabbit mAb

Ucallm_WR6097-50

Price range: $268.00 through $328.00

Size

50μl

Clear

SKU: WR6097-50

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Product details

Background:The protein encoded by this gene is the CD3-epsilon polypeptide , which together with CD3-gamma , -delta and -zeta , and the T-cell receptor alpha/beta and gamma/delta heterodimers , forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon , gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq , Jul 2008] ,

Specifications

Size	50μL/100μL
Target	CD3E
Reactivity	Mouse, Rat
Applications	WB, IHC, IF, IP, ELISA
MW(Calculated)	23kD
MW(Observed)	23kD
Host Species	Rabbit
Isotype	IgG, Kappa
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Purification	Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
Storage	-15°C to -25°C/1 year (Do not lower than -25°C)
Concentration
Clonality	Monoclonal
Clone Number	RM2112R
Immunogen	The specific immunogen used to produce this antibody is proprietary information.
Specificity	Endogenous
Gene Name	CD3E T3E
Protein Name	CD3, CD3E
Other Name	T-cell surface glycoprotein CD3 epsilon chain; / T-cell surface antigen T3/Leu-4 epsilon chain; / CD antigen CD3e
Species	Human
Gene ID	916
Uniprot	P07766,
Species.1	Mouse
Gene ID.1
Uniprot.1	P22646
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Membranous
Tissue Expression	Membranous
Signaling_pathway	Organismal Systems >> Immune system >> Hematopoietic cell lineage;Organismal Systems >> Immune system >> T cell receptor signaling pathway;Organismal Systems >> Immune system >> Th1 and Th2 cell differentiation;Organismal Systems >> Immune system >> Th17 cell differentiation;Human Diseases >> Cancer: overview >> PD-L1 expression and PD-1 checkpoint pathway in cancer;Human Diseases >> Immune disease >> Primary immunodeficiency
Research Areas	>>Hematopoietic cell lineage; / >>Th1 and Th2 cell differentiation; / >>Th17 cell differentiation; / >>T cell receptor signaling pathway; / >>Chagas disease; / >>Measles; / >>Human T-cell leukemia virus 1 infection; / >>Epstein-Barr virus infection; / >>Human immunodeficiency virus 1 infection; / >>PD-L1 expression and PD-1 checkpoint pathway in cancer; / >>Primary immunodeficiency
Function	Function:The CD3 complex mediates signal transduction. ,online information:CD3E mutation db ,similarity:Contains 1 Ig-like (immunoglobulin-like) domain. ,similarity:Contains 1 ITAM domain. ,subunit:The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma , delta , epsilon , zeta , and eta. ,