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Background：Solute carrier family 34 member A2 (SLC34A2), also known as NaPi2b, pH-sensitive sodium-dependent phosphate transporter, which belongs to the solute carrier (SLC) family. The SLC34 family consists of three sodium-dependent phosphate transporters, A1, A2, and A3, that carry the monovalent form phosphate into cells. SLC34A2 is a sodium dependent inorganic phosphate (Pi) transporter that regulates phosphate homeostasis in various organs, including the small intestine, lung, liver, and testis. In the small intestine, NaPi-2b localizes to the intestinal brush border membrane to mediate Pi reabsorption. In the lung, NaPi-2b is expressed in the apical membrane of type II alveolar cells and is involved in the synthesis of surfactant. Mutations in the corresponding SLC34A2 gene causes pulmonary alveolar microlithiasis, a rare autosomal recessive disorder characterized by the deposition of calcium phosphate microliths throughout the lungs. Research studies show aberrant expression of NaPi-2b in various type of cancer, including ovarian, breast, and lung cancer. Chromosomal rearrangements involving SLC34A2-ROS1 are seen in gastric.
