U-Blot® CD3E×BCMA hIgG4 Reference Antibody (Tecbio)

$999.00

SKU: WE2710-50
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Product details

Background:Teclistamab is a Bispecific monoclonal antibody that enhances the immune system’s ability to attack cancer cells by targeting two different antigens at once. It specifically binds to B cell maturation antigen (BCMA) and CD3 molecules on the surface of T cells, forming a“Bridge” that enables T cells to recognize and contact myeloma cells more efficiently. When Teclistamab binds to CD3, it activates T cells, prompting them to release cytokines that mediate the killing of tumor cells and thus promote their death. In addition, Teclistamab directs T cells to the tumor microenvironment, further enhancing the body’s anti-tumor immune response. This mechanism dramatically improves the effectiveness of Teclistamab in treating multiple myeloma.

Specifications

TargetCD3E&BCMA
Reactivity
ApplicationsFlow Cytometry; Aassay
MW(Calculated)
MW(Observed)
Host SpeciesHuman
IsotypeIgG4
Conjugate/ModificationUnconjugated
Modification
Recommended Dilution Ratio
Formulation BufferPhosphate-buffered solution, pH 7.2-7.4.
Source
Purification
Purity> 95% as determined by SDS-PAGE
StorageStore at 2-8℃ short term (1-2 weeks).Store at ≤ -64℃ long term.Avoid repeated freeze-thaw.
Concentration
Clonality
Clone Numberteclistamab
Immunogen
Sequence
Specificity
Gene Name
Protein Name
Other NameCD3E: CD3epsilon, IMD18, T3E, TCREBCMA: BCM, TNFRSF17, CD269, TNFRSF13A
Species
Gene ID
Uniprot
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Organism-4
GeneID-4
SwissProt-4
Cellular Localization
Tissue Expression
Signaling_pathway
Research Areas
Function
RRID
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