SKU: WP0819 Categories: ,

ABLM1 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP0819-100
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Product details

Background:

This gene encodes a cytoskeletal LIM protein that binds to actin filaments via a domain that is homologous to erythrocyte dematin. LIM domains, found in over 60 proteins, play key roles in the regulation of developmental pathways. LIM domains also function as protein-binding interfaces, mediating specific protein-protein interactions. The protein encoded by this gene could mediate such interactions between actin filaments and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],

Specifications

Size50μL/100μL
TargetABLM1
ReactivityHuman, Mouse
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)85kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human protein . at AA range: 520-600
SpecificityABLM1 Polyclonal Antibody detects endogenous levels of protein.
Gene NameABLIM1 ABLIM KIAA0059 LIMAB1
Protein NameActin-binding LIM protein 1 (abLIM-1) (Actin-binding LIM protein family member 1) (Actin-binding double zinc finger protein) (LIMAB1) (Limatin)
Other Name
SpeciesHuman
Gene ID3983
UniprotO14639,
Species.1Mouse
Gene ID.1
Uniprot.1Q8K4G5
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCytoplasm . Cytoplasm, cytoskeleton . Associated with the cytoskeleton. .
Tissue ExpressionDetected in liver, heart, skeletal muscle, brain and retina, where it is concentrated in the inner segment and in the outer plexiform layers.
Signaling_pathway
Research Areas>>Axon guidance
FunctionFunction:May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 HP (headpiece) domain.,similarity:Contains 2 LIM zinc-binding domains.,similarity:Contains 4 LIM zinc-binding domains.,subcellular location:Associated with the cytoskeleton.,subunit:Binds F-actin. Interacts with ABRA.,tissue specificity:Detected in liver, heart, skeletal muscle, brain and retina, where it is concentrated in the inner segment and in the outer plexiform layers.,
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