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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/SUMO3 Polyclonal Antibody
SKU: WP2308 Categories: ,

SUMO3 Polyclonal Antibody

Ucallm_WP2308-50

Price range: $268.00 through $328.00

SKU: WP2308-100
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Product details

Background:

This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Feb 2014],

Specifications

Size50μL/100μL
TargetSUMO3
ReactivityHuman, Mouse, Rat
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)11kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000; ELISA 1:5000-20000
FormulationLiquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from part region of human protein AA range: 1-50
SpecificitySUMO3 Polyclonal Antibody detects endogenous levels of protein.
Gene NameSUMO3 SMT3B SMT3H1
Protein NameSmall ubiquitin-related modifier 3 (SUMO-3) (SMT3 homolog 1) (SUMO-2) (Ubiquitin-like protein SMT3B) (Smt3B)
Other Name
SpeciesHuman
Gene ID6612
UniprotP55854,
Species.1Mouse
Gene ID.1
Uniprot.1Q9Z172,
Species.2Rat
Gene ID.2
Uniprot.2Q5XIF4
Cellular LocalizationCytoplasm. Nucleus. Nucleus, PML body .
Tissue ExpressionExpressed predominantly in liver.
Signaling_pathwayGenetic Information Processing >> Translation >> Nucleocytoplasmic transport
Research Areas>>Nucleocytoplasmic transport; / >>Fluid shear stress and atherosclerosis
FunctionFunction:Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4.,online information:SUMO protein entry,PTM:Cleavage of precursor form by SENP1 or SENP2 is necessary for function.,PTM:Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function.,PTM:Polymeric chains can be formed through Lys-11 cross-linking.,similarity:Belongs to the ubiquitin family. SUMO subfamily.,similarity:Contains 1 ubiquitin-like domain.,subcellular location:Nuclear bodies.,subunit:Homotrimer (Potential). Crystal packing analysis suggests a possible trimeric assembly, of which the biological significance remains to be determined. Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins. Interacts with PELP1.,subunit:Interacts with SAE2 and UBE2I. Covalently attached to a number of proteins.,tissue specificity:Broadly expressed.,tissue specificity:Expressed predominantly in liver.,
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