Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | FKBP8 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 45kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Specificity | FKBP8 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | FKBP8 FKBP38 |
| Protein Name | Peptidyl-prolyl cis-trans isomerase FKBP8 (PPIase FKBP8) (38 kDa FK506-binding protein) (38 kDa FKBP) (FKBP-38) (hFKBP38) (FK506-binding protein 8) (FKBP-8) (FKBPR38) (Rotamase) |
| Other Name | |
| Species | Human |
| Gene ID | 23770 |
| Uniprot | Q14318, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | O35465, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | Q3B7U9 |
| Cellular Localization | Mitochondrion . Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side .; [Isoform 1]: Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side .; [Isoform 3]: Mitochondrion membrane; Single-pass membrane protein; Cytoplasmic side . |
| Tissue Expression | Widely expressed. Highest levels seen in the brain. Highly abundant in the retina. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Mitophagy - animal |
| Research Areas | |
| Function | Catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,Caution:It is uncertain whether Met-1 or Met-58 is the initiator.,cofactor:Calcium.,Function:Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis.,miscellaneous:Binds the immunosuppressant FK506 only in its calmodulin/calcium activated form.,sequence Caution:The first part of the cDNA maps to the same locus, but in opposite orientation.,similarity:Contains 1 PPIase FKBP-type domain.,similarity:Contains 3 TPR repeats.,subunit:Homomultimers or heteromultimers (Potential). Forms heterodimer with calmodulin. When activated by calmodulin and calcium, interacts with the BH4 domain of BCL2 and weakly with BCLX isoform Bcl-X(L). Does not bind and inhibit calcineurin. Interacts with HCV NS5A.,tissue specificity:Widely expressed. Highest levels seen in the brain., |
