Name: WASL Polyclonal Antibody
SKU: WP2714
Price: 268 USD
Availability: InStock

WASL Polyclonal Antibody

Ucallm_WP2714-50

Price range: $268.00 through $328.00

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50μl

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SKU: WP2714-100

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Product details

Background:

This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. [provided by RefSeq, Jul 2013],

Specifications

Size	50μL/100μL
Target	N WASP
Reactivity	Human, Mouse, Rat
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	55kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-2000; ELISA 1:5000-20000
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from human protein . at AA range: 190-270
Specificity	WASL Polyclonal Antibody detects endogenous levels of protein.
Gene Name	WASL
Protein Name	Neural Wiskott-Aldrich syndrome protein (N-WASP)
Other Name
Species	Human
Gene ID	8976
Uniprot	O00401,
Species.1	Mouse
Gene ID.1
Uniprot.1	Q91YD9,
Species.2	Rat
Gene ID.2
Uniprot.2	O08816
Cellular Localization	Cytoplasm, cytoskeleton . Nucleus . Cytoplasm . Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated (By similarity). Exported from the nucleus by an nuclear export signal (NES)-dependent mechanism to the cytoplasm (By similarity). .
Tissue Expression	Brain,Liver,
Signaling_pathway	Cellular Processes >> Cellular community - eukaryotes >> Adherens junction;Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton
Research Areas	>>Endocytosis; / >>Adherens junction; / >>Regulation of actin cytoskeleton; / >>Bacterial invasion of epithelial cells; / >>Pathogenic Escherichia coli infection; / >>Shigellosis; / >>Salmonella infection; / >>Yersinia infection
Function	Function:Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression.,similarity:Contains 1 CRIB domain.,similarity:Contains 1 WH1 domain.,similarity:Contains 2 WH2 domains.,subcellular location:Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated.,subunit:Binds actin and the Arp2/3 complex. Interacts with CDC42. Binds to SH3 domains of GRB2. Interacts with the C-terminal SH3 domain of DNMBP. Interacts with the WW domains of PRPF40A/FBP11 (By similarity). Interacts with NOSTRIN. Interacts with Shigella flexneri protein icsA. The interaction with icsA enhances the affinity of WASL for Arp2/3, thus assembling a tight complex which has maximal activity in actin assembly.,

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WASL Polyclonal Antibody

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WASL Polyclonal Antibody

Product details

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