Price range: $268.00 through $328.00
Background:
This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010],
| Size | 50μL/100μL |
| Target | CCDC6 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 52kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human CCDC6 AA range: 104-154 |
| Specificity | This antibody detects endogenous levels of CCDC6 at Human/Mouse |
| Gene Name | CCDC6 D10S170 TST1 |
| Protein Name | CCDC6 |
| Other Name | |
| Species | Human |
| Gene ID | 8030 |
| Uniprot | Q16204, |
| Species.1 | Mouse |
| Gene ID.1 | 76551 |
| Uniprot.1 | D3YZP9 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm. Cytoplasm, cytoskeleton . May be a cytoskeletal protein. |
| Tissue Expression | Ubiquitously expressed. |
| Signaling_pathway | Human Diseases >> Cancer: overview >> Pathways in cancer;Human Diseases >> Cancer: specific types >> Thyroid cancer |
| Research Areas | >>Pathways in cancer; / >>Thyroid cancer |
| Function | Disease:A chromosomal aberration involving CCDC6 is a cause of thyroid papillary carcinoma (PACT) [MIM:188550]. Inversion inv(10)(q11.2; q21) generates the RET/CCDC6 (PTC1) oncogene.,Domain:The protein has mostly an alpha helical conformation similar to myosin heavy-chain tail that might adopt a coiled-coil conformation.,subcellular location:May be a cytoskeletal protein.,tissue specificity:Ubiquitously expressed., |
