Product details
Background:
ARP2 rabbit pAb
Ucallm_WP6214-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | ACTR2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 43kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ARP2 |
| Specificity | This antibody detects endogenous levels of ARP2 at Human, Mouse,Rat |
| Gene Name | ACTR2 ARP2 |
| Protein Name | Actin-related protein 2 (Actin-like protein 2) |
| Other Name | |
| Species | Human |
| Gene ID | 10097 |
| Uniprot | P61160, |
| Species.1 | Mouse |
| Gene ID.1 | 66713 |
| Uniprot.1 | P61161, |
| Species.2 | Rat |
| Gene ID.2 | 289820 |
| Uniprot.2 | Q5M7U6 |
| Cellular Localization | Cytoplasm, cytoskeleton . Cell projection . Nucleus . |
| Tissue Expression | |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Tight junction;Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Organismal Systems >> Immune system >> Fc gamma R-mediated phagocytosis |
| Research Areas | |
| Function | ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) . The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility . Seems to contact the pointed end of the daughter actin filament . In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation . In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA . The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) . |
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