Product details
Background:
TEAD4 rabbit pAb
Ucallm_WP6340-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | TEF-3 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 48kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human TEAD4 |
| Specificity | This antibody detects endogenous levels of TEAD4 at Human, Mouse |
| Gene Name | TEAD4 RTEF1 TCF13L1 TEF3 |
| Protein Name | Transcriptional enhancer factor TEF-3 (TEA domain family member 4) (TEAD-4) (Transcription factor 13-like 1) (Transcription factor RTEF-1) |
| Other Name | |
| Species | Human |
| Gene ID | 7004 |
| Uniprot | Q15561, |
| Species.1 | Mouse |
| Gene ID.1 | 21679 |
| Uniprot.1 | Q62296 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus. |
| Tissue Expression | Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart. |
| Signaling_pathway | Environmental Information Processing >> Signal transduction >> Hippo signaling pathway;Environmental Information Processing >> Signal transduction >> Hippo signaling pathway - multiple species |
| Research Areas | |
| Function | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. |
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