Product details
Background:
HLTF rabbit pAb
Ucallm_WP6693-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | HLTF |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 111kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human HLTF |
| Specificity | This antibody detects endogenous levels of HLTF at Human, Mouse |
| Gene Name | HLTF HIP116A RNF80 SMARCA3 SNF2L3 ZBU1 |
| Protein Name | Helicase-like transcription factor (DNA-binding protein/plasminogen activator inhibitor 1 regulator) (HIP116) (RING finger protein 80) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3) (Sucrose nonfermenting protein 2-like 3) |
| Other Name | |
| Species | Human |
| Gene ID | 6596 |
| Uniprot | Q14527, |
| Species.1 | Mouse |
| Gene ID.1 | 20585 |
| Uniprot.1 | Q6PCN7 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . Nucleus . Nucleus, nucleolus . Nucleus, nucleoplasm . Nuclear localization is stimulated by progesterone. . |
| Tissue Expression | Expressed in brain, heart, kidney, liver, lung, pancreas, placenta and skeletal muscle. |
| Signaling_pathway | |
| Research Areas | |
| Function | Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. |
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